FAQs

NAD+ is short for Nicotinamide adenine dinucleotide and it is a co-enzyme that is critical for life. It is found, naturally, in every living cell in your body where it plays an important part in over 200 biological pathways.

NAD+ is essential in the Krebs Cycle, which turns food molecules into energy. It enables DNA repair and cellular regeneration. NAD+ also works with the neuro-transmission of signals between neurons (including in the brain).

Lower levels of NAD+ result in your cells being unable to metabolise as much of the food molecules that are needed, making less energy available for you to use. As cells replicate DNA is damaged and, without repairing this damage copies of this damage can be passed on to future replications of the cells. Without the NAD+ supporting neurotransmission between cells, so the signal generated by one neuron is not passed on as efficiently as possible to the next, leading to a weaker, slower signal. These slow signals add up to cogitative slowing and even cogitative decline.

There are four main routes which can be used to top up your NAD+ levels.

1. Orally: NAD+ can be swallowed in pill form, but the bioavailability (the amount your body can absorb) is extremely low as NAD+ is a fragile molecule and is broken down during digestion. NAD+ precursor molecules (such as NMN and NR) can also be consumed and are more stable through digestion but there are questions over the safety of such supplements. The FDA is currently investigating NMN as there may be unintended consequences, possibly as severe as cancer, caused by heavy consumption of these supplements.
2. Intravenous injection: The fastest way to boost your NAD+ levels is through IV drip, where 500mg/1000mg of NAD+ can be administered in a matter of hours. The downside of this is that the experience can be unpleasant, with strong tightening of the chest, waves of nausea and abdominal pain. It also requires someone trained in canulation (eg a nurse) to administer and can take 2 hours or more. The huge boost to the system is an excellent way to get to optimal NAD+ levels immediately, but wears off over time unless administered again or supplemented in another way, such as intramuscular or subcutaneous injections (see below)
3. Intramuscular injection: An effective way to maintain NAD+ levels in the body is to have small IM injections of NAD+ multiple times a month. This tops-up the system effectively, but has its own side effect of being an extremely painful injection into the muscle. It also requires “drawing up” (taking the NAD+ from a vial into the syringe) and involves long needles, which many customers are uncomfortable with. Finally, the IM injection requires the customer to find someone to inject them or for them to inject themselves, which is also tricky for many customers.
4. Sub-cutaneous injection (sub.cut.): The VAION+ PEN was the first sub.cut. auto-injector pen for NAD+. It precisely administers the right amount of NAD+ 4mm under the skin… which is exactly where the fatty layer is. This fatty layer has fewer nerves than muscle and a slower blood flow, resulting in significantly less painful injection. The dose is small and administered every other day to build up and then maintain your healthy NAD+ levels.
5. Nasal Spray: The VAION+ Nasal Spray is different from many other NAD+ nasal sprays in the market because we dont need to use any solvents or stabilizers when we make it. This makes the spray clean, pure and does not impede the NAD+ from crossing the nasal membrane.

Colour Differences Between NAD⁺ and NADH

• NAD⁺ (Nicotinamide Adenine Dinucleotide, oxidized form): In its pure state, NAD⁺ is a white, hygroscopic powder that dissolves into a colourless solution. Under certain conditions, such as pH variations, the solution may appear slightly yellow. However, a dark or brown coloration can indicate degradation or contamination. ​
• NADH (Reduced form of NAD⁺): NADH naturally has a light yellow colour in solution, which becomes more noticeable at higher concentrations. This coloration is due to its distinct absorption properties in the ultraviolet spectrum. ​

Implications for Product Quality

The coloration of NAD⁺ solutions can serve as an indicator of purity. A clear or very pale yellow solution suggests high purity, while a more pronounced yellow or brown tint may indicate the presence of NADH or degradation products. Therefore, maintaining a clear or very pale yellow appearance in your NAD⁺ products supports your claim of superior quality.

Using the VAION PEN, you should build up your NAD+ levels over the first three days of use by taking a dose on day 1, 2 and 3. After the first three days, you should use your VAION PEN every other day. We recommend taking the NAD+ in the morning so you can enjoy the benefits of your top up throughout the day.

Using the VAION Nasal Spray, you should take one puff in each nostril once a day, ideally first thing in the morning.

Unless otherwise told by a qualified medic, you should take 30 units on the VAION pen dose meter (50mg) of NAD+ per injection. For three days, take it every day, then every other day thereafter.

Using the VAION Nasal Spray, you should take one puff (25mg) in each nostril once a day, ideally first thing in the morning.

The VAION PEN is the easiest, and most convenient way to top up your NAD+ levels at the highest bioavailability for those who do not mind needles.

If you are uncomfortable injecting yourself, we recommend the VAION NASAL SPRAY, as it is very convenient and easy, does not require needles but is less bioavailable compared to the injector pen.

INSERT/REPLACE THE NAD+ CARTRIDGE
1. Remove the lid by pulling it away from the base
2. Unscrew the clear glass piece from the base
3. Push down the black plunger with your finger to reset it
4. Slide a new cartridge into the clear holder and, with the metal cap facing the top if the pen, reattaching it by screwing on firmly.

1. Remove the lid from the pen & check that the cartridge has enough NAD+ solution in it. If not,
2. Take a 4mm needle tip from the pack and gently but firmly screw it on to the end of the pen. Do not remove the needle tip cover yet.
3. Clean the injection site with an alcohol wipe provided in the pack. It is good to select a fatty area, such as the belly, buttock or thigh.
4. Remove the needle tip covers (there is an inner and an outer one – remove both)
5. Without putting the pen down, twist the base until the pointer lines up with your dose, usually 30 units, which is 0.3ml.
6. Hold the pen so the needle points up. Tap the pen few times to move the air bubble to the top and slide the plunger enough to push the air out before you give the shot.
7. Gently pinch the skin around the injection site to pull it away from the muscle a little (it only needs to be 4mm away so don’t pull hard!)
8. Place the pen on the injection site & press the pen down to penetrate skin.
9. Firmly press the button at the base of the pen. This will depress the plunger and administer the NAD+. A slight stinging sensation is normal.
10. Once the dial has returned to zero (0), count down three seconds to ensure the entire dose is administered and then remove the needle.
11. Remove the pen cover, replace the larger needle tip cover carefully & unscrew the needle tip + cover.
12. Put the pen lid back on & dispose of the needle tip in your regular household waste.

The NAD+ (for the pen or the nasal spray) should be stored, with its active cartridge of NAD+, between 2 and 8 degrees Celsius (35.6-46.4 Fahrenheit). A domestic fridge is a great place. If you are travelling, it is highly recommended to use an insulated case with ice packs.

NAD+ cartridges that are not yet being used should also be stored in the fridge.

VAION’s NAD+ can last for 12 months if kept chilled, at the correct temperature. We are incredibly careful to make sure that you are only buying the freshest NAD+ from us, and so have put expiry dates on the vials. Please reference these and do not use any NAD+ that has passed these dates.

The main reason why your injection might be stinging is normally injection technique. Here are some tips that should reduce or stop the sting:

1. Remove the cap – you will have more control and are more likely to go through the skin to the fatty layer underneath. Injecting into the fat will sting less as there are fewer nerves than in the skin.
2. Hold part of the pen that holds the cartridge (clear glass section) in your hand for 30s to 1 min to warm the liquid (cold injections sting more).
3. Give yourself small pinches across your stomach, hips and thighs to see which area hurts the least. This area is likely to have the fewest nerves.
4. Hold the pen so your thumb will push the end of the pen, not your finger. Your thumb is stronger and, as such, the pen will move less when you administer.
5. When you have identified your preferred area, gently pinch the skin and pull away from the body. DO NOT grab a handful of flesh, as this will also pull the interstitial tissue, muscle etc towards the injection too. Just gently pull the skin away from the body and inject into the fold of skin. If it helps, try bending over slightly to make the fold of skin easier to grab.
6. Push the plunger slowly. It should take around 7-10 seconds to administer the injection. Then wait for 3 more seconds before taking the needle out to ensure all the NAD+ has been administered.
7. Finally, pull the needle out the way it went in. Do not change the angle of the pen, as this causes the needle to wiggle inside you, cutting capillaries and causing bruising.

The NAD+ must remain chilled in transit, so we use some specially designed packaging, with integrated cooling, to be certain that you get your NAD+ in the best possible condition. The packaging and cooling will maintain the right temperature for 48 hours (2 days) so when there are expected delays with postage (such as over bank weekends), we may delay shipping to ensure your NAD+ doesn’t sit for too long and warm up.

YES. Your cartridges can contain 3ml when filled to the top, but doing so makes it much more likely for the bung to come out in transit. As a result, we sent you two cartridges with just over 3ml in each. We slightly over-fill each cartridge so you get every dose you need throughout the month, despite losing a few drops along the way (clearing any bubbles, discarded with the needle, human error etc).

The packages need to remain temperature controlled and the packaging we use cools and insulates for 24 hours. Because of this narrow time window, all deliveries are sent at 1pm Mon-Thurs with a guaranteed next day delivery. If the order is placed after 2pm, it will be sent the following day. Please note that we do not ship on a Friday to prevent the product spending the weekend in transit.

When NAD+ degrades, either due to temperature or oxidation through exposure to the air, it changes colour.

Perfect NAD+ is clear, like water. This is how we make it and how we hope you take it.

Good NAD+ can be a pale straw colour. This is also fine to take, but no longer has as much active NAD+ as it could.

Bad NAD+ has an orange tint to it and should be avoided at all costs.

If your NAD+ has a colour you are worried about, please email a photo of the vial against a white background to support@vaion.io and put it back in the fridge (no not take it) until we are able to advise you.

There is conflicting evidence as to the effect of NAD+ on different types of cancer. In some studies, NAD+ has been thought to accelerate cancer cell metabolism, and in others it has been seen to help fight cancer cells. As a result, VAION will not knowingly sell any NAD+ products if you have had cancer of any sort in the past 3 years. If you have/have had cancer and still want to purchase NAD+ products please email support@vaion.io providing a signed letter from your oncologist stating that it is safe for you.

Please note that your safety is the single most important thing to us and we made this choice out of an abundance of caution.

We over-fill every pen so you you get 20 doses which last over a month, so don’t worry if you lose a bit after an injection. However, to prevent this happening, make sure to leave the needle tip inside the skin for a count of 3 seconds to ensure all the NAD+ enters your system and isn’t wasted.

Yes. This is normal, although not everyone gets it.

The red mark can be the size of a 50p piece, a 5p piece or it can be completely absent. This is individual and reflects your skin’s sensitivity to the pH of NAD+. If you are someone who gets the red mark, don’t worry, it will disappear after a little while and is causing you no harm, being well within the applicable guidelines for pH of injectables.

If you are worried about the appearance of the mark, consider injecting in area that is covered by clothing, such as the buttock.

No. They are not the same, but they are related.

Vitamin B3, also known as niacin, includes several compounds such as nicotinic acid, nicotinamide, and nicotinamide riboside. These compounds are precursors that the body converts into NAD+, not NAD+ itself. Your NAD+ levels will be helped by having more “building blocks” to make into NAD+, but supplementing your NAD+ is the most effective way of boosting NAD+ levels.

Every body is different and everyone’s NAD+ levels in their bodies are different. Because of this, there is no standard experience, but there are some common traits that many people feel after their first injection:

1. A rush of excited energy that some say feels like drinking too much coffee. This passes in a short while and, over a few days will stop happening.
2. Tingling of fingers and/or the back of the head. This passes quickly and stops happening quickly too.
3. A sense of focus, clarity of thought and/or better vision with colours standing out more vividly.
4. Tiredness or lethargy can be experienced by those with low resting NAD+ levels and is normal while bring levels up

Feeling tired after an NAD+ injection is a common side effect for some people. This fatigue can occur during the infusion or develop over the next day or two. Here are a few reasons why this might happen:

1. Adjustment Period: Your body might need time to adjust to the increased levels of NAD+. This adjustment can temporarily make you feel tired as your cells adapt to the new energy dynamics.
2. Detoxification: NAD+ plays a role in cellular repair and detoxification. As your body starts to repair and detoxify, it can lead to temporary fatigue.
3. Energy Redistribution: NAD+ is crucial for energy production in cells. Initially, your body might redirect energy towards essential repair processes, leaving you feeling temporarily drained.

This tiredness is usually temporary and should resolve within an few doses.

VAION NAD+ products all come with a unique Securicode attached to the NAD+ containing cartridge/bottle. Please download the Securicode app and scan this barcode to be sure it is genuine. If the App flags your product as not being genuine, please contact support@vaion.io or wherever you bought the product immediately and do not take it.